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Case 3: 3-year-old Female with Abdominal Pain

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Go to: SRBCT page, Neuroblastoma page

Go to: Clinical Presentation, Light Microscopy, IHC

Clinical Presentation

A previously healthy 3-year-old female presented with intermittent sharp abdominal pain.

Radiology:

CT (left) and MIBG scan (right)
  • CT chest: a retroperitoneal mass, measuring 12.9 x 11.1 x 8.2 cm, arising in the right adrenal gland and extending into the hilum of the right kidney.
  • MIBG scan showed MIBG accumulation at the site of the intra-abdominal mass.

Go to: Clinical Presentation, Light Microscopy, IHC

Light Microscopic Findings

Small round blue cells with prominent nuclei and increased mitoses and karyorrhexis (MYCN amp histology); no neuropil production

Immunohistochemical Staining

Go to: Clinical Presentation, Light Microscopy,IHC

IHC panel for SRBCTs

Go to: SRBCT page

Immunohistochemical Staining

Phox2b IHC: diffuse strong nuclear positivity
TH (Tyrosin hydroxylase): negative
  • Negative: myogenin, desmin, WT1, NKX2.2, CD99

Diagnosis?

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