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Case 3: 3-year-old Female with Abdominal Pain

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Go to: SRBCT page, Neuroblastoma page

Go to: Diagnosis, Molecular Testing, Discussion, Pathology Summary

Diagnosis

Neuroblastoma (Schwannian stroma-poor), undifferentiated subtype, high MKI, 3 years of age, Unfavorable Histology

Go to: Diagnosis, Molecular Testing, Discussion, Pathology Summary

Molecular Testing

MYCN FISH

FISH analysis with probes for MYCN (green) and chromosome 2 centromere (orange) revealed amplification of MYCN
  • MYCN gene amplification is a recurrent driver alteration in neuroblastoma associated with a poor prognosis.

Next Generation Sequencing (OncoKids)

  • NGS also detect MYCN gene amplification
  • MYCN gene amplification is a recurrent driver alteration in neuroblastoma associated with a poor prognosis.

Chromosomal Microarray

Amplification involving the MYCN locus in 2p24.3p24.2
  • MYCN gene amplification is a recurrent driver alteration in neuroblastoma associated with a poor prognosis.

Go to: Diagnosis, Molecular Testing, Discussion, Pathology Summary

Discussion

Go to: Neuroblastoma page

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